Heart Failure Abstract

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HeartFailure Abstract

HeartFailure Abstract

Heartfailure with preserved ejection fraction commonly referred to asHFPEF have been observed to constitute over half of older adult`sheart failures. Over the years the prevalence of the condition hasbeen on the rise while its treatment has remained empirical. Theguidelines for managing the disease has been largely founded onconsensus from experts which in most cases fail to understand thedevelopment and progression of HFPEF. It has been observed that highsodium diets can be used as predictors of hypertension across adiverse group of the population especially those with highsensitivity to salt. High sodium intake results in the induction ofgeneral hypertension, stress caused by oxidation and damage to thecardiovascular system. It is critical to note that factors thatforecast an individual`s salt sensitivity hypertension closely relateto HFPEF condition. To analyze this dietary modification study needsto be conducted concerning its effect on HFPEF (Hummel, Seymour,Brook, Kolias, Sheth, Rosenblum, Wells &amp Weder 2012). This studywill evaluate dietary changes in preventing hypertension coupled withsodium restriction and measure its effects on HFPEF. Theinvestigation will conform to the Helsinki Declaration as approved byInstitutional Review Board of the University of Michigan.Participants will have to go through inclusion and exclusion criteriabefore the study begins. The study will take a duration of threeweeks where it is hypothesized that dietary changes to stophypertension coupled with sodium restriction have the same effect onHFPEF patients (Hummel et al., 2012). The subjects will be placed ona diet prepared by research dietitians for 25 days with a two-daytesting period before and after day 21. The study will test theirblood pressure, and cardiovascular functions before carrying out astatistical analysis. This will be the initial study to examine thephysiological impact of dietary changes on HFPEF. Therefore, it istheorized that dietary modification can be used to reduce bloodpressure and arterial stiffness significantly.


HummelSL, Seymour M, Brook RD, Kolias TJ, Sheth SS, Rosenblum HR, Wells JM,WEder AB. (2012). Low-Sodium Dietary Approaches to Stop HypertensionDiet Reduces Blood Pressure, Arterial Stiffness, and Oxidative Stressin Hypertensive Heart Failure With Preserved Ejection Fraction.Hypertension,60(5), 1200-1206.http://dx.doi.org/10.1161/hypertensionaha.112.202705